POLE3

Across TCGA cell cohorts, POLE3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,888 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible POLE3-associated GO terms across cancer lineages are Positive regulation of mRNA 3'-end processing, Immunoglobulin heavy chain V-D-J recombination, and Positive regulation of chromosome condensation. Each is linked with POLE3 in more than 19 cancer types. Because this analysis shows association rather than direction, both POLE3-to-partner and partner-to-POLE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of mRNA 3'-end processing grouped by POLE3-low versus POLE3-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POLE3→partner) and Y-score (partner→POLE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Positive regulation of mRNA 3'-end processing →	+0.119	+0.680	.004	.003	3	20
LUNG_NSCLC_LUSC	Immunoglobulin heavy chain V-D-J recombination →	+0.211	+1.040	<.001	<.001	3	20
BLOOD_Myeloma	Positive regulation of chromosome condensation →	+0.226	+1.149	<.001	.005	3	19
LUNG_NSCLC_LUSC	Regulation of G2/M transition of mitotic cell cycle →	+0.090	+1.028	.001	<.001	3	18
BONE	Negative regulation of cell cycle G2/M phase transition →	+0.092	+0.741	<.001	.003	3	18
BLOOD_Myeloma	Interstrand cross-link repair →	+0.094	+1.266	<.001	.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,888 associations by consensus.

Positive regulation of mRNA 3'-end processing by POLE3 expression — OESOPHAGUS

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