POLE2

Across TCGA patient cohorts, POLE2 protein abundance is significantly associated with the RNA expression of many other genes, with 6,067 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible POLE2-associated genes across cancer lineages are CENPW, MYBL2, and CDC20. Each is linked with POLE2 in more than 4 cancer types. Because this analysis shows association rather than direction, both POLE2-to-partner and partner-to-POLE2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, POLE2 versus CENPW in BRCA, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLE2→partner) and Y-score (partner→POLE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CENPW →	+1.071	+0.453	<.001	<.001	3	5
BRCA	MYBL2 →	+1.785	+0.583	<.001	<.001	3	4
BRCA	CDC20 →	+1.903	+0.595	<.001	<.001	3	4
BRCA	HROB →	+0.937	+0.546	<.001	<.001	3	4
BRCA	PKMYT1 →	+1.246	+0.518	<.001	<.001	3	4
LUAD	CEP55 →	+1.270	+0.933	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,067 associations by consensus.

POLE2 vs CENPW — BRCA

Explore this scatter interactively →