POLE2

Across TCGA patient cohorts, POLE2 mutation is significantly associated with the RNA expression of many other genes, with 94 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLE2-associated genes across cancer lineages are ATP6V1G1P1, RNA5SP164, and LINC02342. Each is linked with POLE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both POLE2-to-partner and partner-to-POLE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP6V1G1P1 grouped by POLE2-low versus POLE2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLE2→partner) and Y-score (partner→POLE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ATP6V1G1P1 →	+0.136	+4.867	<.001	.005	3	2
BRCA	RNA5SP164 →	+0.299	+8.471	<.001	.005	3	2
BRCA	LINC02342 →	+0.188	+7.731	<.001	.009	3	1
UCEC	RN7SL219P →	+0.353	+2.913	.005	.008	3	1
UCEC	MIR4445 →	+0.324	+5.478	<.001	<.001	3	1
UCEC	MIR4482 →	+1.611	+3.830	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 94 associations by consensus.

ATP6V1G1P1 by POLE2 expression — SKCM

Explore this box plot interactively →