POLE2

Across TCGA patient cohorts, POLE2 mutation is significantly associated with the immune_cell of many other genes, with 2 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible POLE2-associated genes across cancer lineages are CD4+ Tem and Adipocytes. Each is linked with POLE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both POLE2-to-partner and partner-to-POLE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD4+ Tem grouped by POLE2-low versus POLE2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLE2→partner) and Y-score (partner→POLE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CD4+ Tem →	+0.021	+6.234	<.001	.026	3	1
UCEC	Adipocytes →	+0.027	+2.507	.005	.022	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

CD4+ Tem by POLE2 expression — BRCA

Explore this box plot interactively →