POLE2

Across TCGA cell cohorts, POLE2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,308 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible POLE2-associated GO terms across cancer lineages are Mitotic DNA integrity checkpoint signaling, Cell cycle DNA replication, and DNA replication. Each is linked with POLE2 in more than 18 cancer types. Because this analysis shows association rather than direction, both POLE2-to-partner and partner-to-POLE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic DNA integrity checkpoint signaling grouped by POLE2-low versus POLE2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POLE2→partner) and Y-score (partner→POLE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Mitotic DNA integrity checkpoint signaling →	+0.112	+1.516	<.001	<.001	3	19
BLOOD_Myeloma	Cell cycle DNA replication →	+0.184	+2.263	<.001	<.001	3	19
PANCREAS	DNA replication →	+0.097	+0.908	<.001	<.001	3	19
BONE	DNA-templated DNA replication →	+0.161	+1.319	.002	.001	3	19
BONE	DNA replication initiation →	+0.201	+1.388	.001	<.001	3	19
BONE	DNA recombination →	+0.080	+1.140	.002	.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,308 associations by consensus.

Mitotic DNA integrity checkpoint signaling by POLE2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →