POLE

Across TCGA pan-cancer cohorts, POLE mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of POLE’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where POLE mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types POLE is over-expressed in tumor.

LSCC, CCRCC, and HNSC are the cancer types where POLE tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLE mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	II,III,IV	+0.537	<.001	8	view →
CCRCC	All	All	+0.299	<.001	5	view →
HNSC	All	II,III,IV	+0.250	.001	5	view →
COAD	All	II,III,IV	+0.589	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

POLE–LSCC

Open the LSCC breakdown →