POLE

Across TCGA patient cohorts, POLE mutation is significantly associated with the total protein of many other genes, with 90 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLE-associated genes across cancer lineages are Caspase-7-cleavedD198, ATM, and mTOR_pS2448. Each is linked with POLE in more than 4 cancer types. Because this analysis shows association rather than direction, both POLE-to-partner and partner-to-POLE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by POLE-low versus POLE-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLE→partner) and Y-score (partner→POLE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.316	+3.717	<.001	<.001	3	5
COAD	ATM →	-0.673	-3.239	<.001	<.001	3	4
SKCM	mTOR_pS2448 →	-0.235	-2.459	<.001	.017	3	4
UCEC	C-Raf →	+0.113	+1.169	<.001	.003	3	4
COAD	Cyclin-E2 →	+0.219	+2.725	.006	.002	3	4
LUAD	N-Ras →	-0.087	-2.309	.030	.033	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 90 associations by consensus.

Caspase-7-cleavedD198 by POLE expression — COAD

Explore this box plot interactively →