POLD3

Across TCGA patient cohorts, POLD3 protein abundance is significantly associated with the RNA expression of many other genes, with 15,565 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible POLD3-associated genes across cancer lineages are FANCI, SKA1, and BUB1B. Each is linked with POLD3 in more than 9 cancer types. Because this analysis shows association rather than direction, both POLD3-to-partner and partner-to-POLD3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, POLD3 versus FANCI in GBM, with a Pearson correlation of 0.69.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLD3→partner) and Y-score (partner→POLD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FANCI →	+0.824	+0.385	<.001	<.001	3	10
LUAD	SKA1 →	+1.364	+0.393	<.001	<.001	3	10
HNSC	BUB1B →	+1.145	+0.606	<.001	<.001	3	10
BRCA	PBK →	+1.430	+0.513	<.001	<.001	3	10
BRCA	EXO1 →	+1.104	+0.457	<.001	<.001	3	10
UCEC	DEPDC1B →	+1.096	+0.311	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,565 associations by consensus.

POLD3 vs FANCI — GBM

Explore this scatter interactively →