POLD3

Across TCGA patient cohorts, POLD3 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLD3-associated genes across cancer lineages are MEK1, FoxM1, and FOXO3a_pS318_S321. Each is linked with POLD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both POLD3-to-partner and partner-to-POLD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by POLD3-low versus POLD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLD3→partner) and Y-score (partner→POLD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.402	+2.321	.018	.034	3	2
UCEC	FoxM1 →	+0.274	+2.817	.023	.036	3	1
UCEC	FOXO3a_pS318_S321 →	-0.131	-2.312	.024	.034	3	1
UCEC	ACC_pS79 →	+0.500	+3.700	.001	.001	3	1
UCEC	GATA3 →	-0.192	-2.979	.029	.036	3	1
UCEC	ACC1 →	+0.598	+3.183	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

MEK1 by POLD3 expression — UCEC

Explore this box plot interactively →