POLD3

Across TCGA cell cohorts, POLD3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,610 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible POLD3-associated GO terms across cancer lineages are Microtubule organizing center organization, Centrosome duplication, and Centriole assembly. Each is linked with POLD3 in more than 18 cancer types. Because this analysis shows association rather than direction, both POLD3-to-partner and partner-to-POLD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Microtubule organizing center organization grouped by POLD3-low versus POLD3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POLD3→partner) and Y-score (partner→POLD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Microtubule organizing center organization →	+0.102	+1.379	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Centrosome duplication →	+0.107	+1.438	<.001	<.001	3	19
KIDNEY	Centriole assembly →	+0.095	+0.754	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	DNA strand elongation →	+0.184	+1.686	<.001	<.001	3	18
BONE	Chromosome condensation →	+0.204	+1.418	.002	<.001	3	18
BONE	Regulation of chromosome organization →	+0.118	+1.251	.001	.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,610 associations by consensus.

Microtubule organizing center organization by POLD3 expression — BONE

Explore this box plot interactively →