POLD3

Across TCGA cell cohorts, POLD3 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible POLD3-associated genes across cancer lineages are ZP4, CFHR2, and ECE2. Each is linked with POLD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both POLD3-to-partner and partner-to-POLD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZP4 grouped by POLD3-low versus POLD3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLD3→partner) and Y-score (partner→POLD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZP4 →	+0.012	+4.539	<.001	.007	3	2
BLOOD_Leukemia	CFHR2 →	+0.296	+4.539	<.001	.007	3	2
LARGE_INTESTINE	ECE2 →	+0.353	+4.054	<.001	.004	3	1
LARGE_INTESTINE	DEFA4 →	+0.032	+4.437	<.001	.004	3	1
BLOOD_Leukemia	ZP2 →	+0.177	+4.409	<.001	.005	3	1
BLOOD_Leukemia	HS3ST6 →	+0.009	+4.539	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

ZP4 by POLD3 expression — BLOOD_Leukemia

Explore this box plot interactively →