POLD1

Across TCGA cell cohorts, POLD1 mutation is significantly associated with the RNA expression of many other genes, with 2,090 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POLD1-associated genes across cancer lineages are CBX7, TXN2, and TMED8. Each is linked with POLD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both POLD1-to-partner and partner-to-POLD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBX7 grouped by POLD1-low versus POLD1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLD1→partner) and Y-score (partner→POLD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CBX7 →	+0.898	+3.546	<.001	<.001	3	2
LARGE_INTESTINE	TXN2 →	+0.536	+2.216	<.001	<.001	3	2
LARGE_INTESTINE	TMED8 →	+0.593	+2.130	<.001	<.001	3	2
LARGE_INTESTINE	R3HCC1 →	+0.636	+2.130	.001	<.001	3	2
LARGE_INTESTINE	RAB3A →	+0.841	+3.459	<.001	<.001	3	2
LARGE_INTESTINE	FMO1 →	+0.057	+1.488	.006	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,090 associations by consensus.

CBX7 by POLD1 expression — LARGE_INTESTINE

Explore this box plot interactively →