POLB

Across TCGA patient cohorts, POLB RNA expression is significantly associated with the protein abundance of many other proteins, with 12,866 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible POLB-associated proteins across cancer lineages are NSD3, ASH2L, and VDAC3. Each is linked with POLB in more than 6 cancer types. Because this analysis shows association rather than direction, both POLB-to-partner and partner-to-POLB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, POLB versus NSD3 in LSCC, with a Pearson correlation of 0.49.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (POLB→partner) and Y-score (partner→POLB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NSD3 →	+0.613	+0.690	<.001	<.001	3	7
LSCC	ASH2L →	+0.446	+0.904	<.001	<.001	3	6
OV	VDAC3 →	+0.658	+0.738	<.001	.001	3	6
BRCA	AP3M2 →	+0.354	+0.822	<.001	<.001	3	5
OV	GPAT4 →	+0.471	+0.745	.001	<.001	3	5
LSCC	ATAD2_S342 →	+0.925	+0.512	.002	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,866 associations by consensus.

POLB vs NSD3 — LSCC

Explore this scatter interactively →