POLB

Across TCGA patient cohorts, POLB protein abundance is significantly associated with the RNA expression of many other genes, with 11,811 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible POLB-associated genes across cancer lineages are RNF170, KAT6A, and NSD3. Each is linked with POLB in more than 7 cancer types. Because this analysis shows association rather than direction, both POLB-to-partner and partner-to-POLB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, POLB versus RNF170 in HNSC, with a Pearson correlation of 0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLB→partner) and Y-score (partner→POLB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNF170 →	+0.643	+0.390	.001	<.001	3	8
HNSC	KAT6A →	+0.600	+0.397	<.001	<.001	3	8
LSCC	NSD3 →	+0.976	+0.522	<.001	<.001	3	7
HNSC	FNTA →	+0.507	+0.339	<.001	<.001	3	7
HNSC	SMIM19 →	+0.672	+0.327	<.001	<.001	3	7
BRCA	GPAT4 →	+0.749	+0.436	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,811 associations by consensus.

POLB vs RNF170 — HNSC

Explore this scatter interactively →