POLB

Across TCGA patient cohorts, POLB protein abundance is significantly associated with the protein abundance of many other proteins, with 21,320 significant associations in total. GBM shows the largest number of these associations.

The most reproducible POLB-associated proteins across cancer lineages are XRCC1, PRPF4, and ASH2L. Each is linked with POLB in more than 9 cancer types. Because this analysis shows association rather than direction, both POLB-to-partner and partner-to-POLB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, POLB versus XRCC1 in GBM, with a Pearson correlation of 0.74.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (POLB→partner) and Y-score (partner→POLB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	XRCC1 →	+0.388	+0.336	<.001	<.001	3	10
GBM	PRPF4 →	+0.254	+0.315	<.001	<.001	3	10
LSCC	ASH2L →	+0.462	+0.431	<.001	<.001	3	10
GBM	SF3A1 →	+0.284	+0.348	<.001	<.001	3	9
GBM	SF3B2 →	+0.239	+0.321	<.001	<.001	3	9
GBM	SMARCC2 →	+0.322	+0.308	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,320 associations by consensus.

POLB vs XRCC1 — GBM

Explore this scatter interactively →