POLB

Across TCGA cell cohorts, POLB RNA expression is significantly associated with the go_rna of many other GO terms, with 3,333 significant associations in total. BONE shows the largest number of these associations.

The most reproducible POLB-associated GO terms across cancer lineages are Interkinetic nuclear migration, Clathrin-coated vesicle cargo loading, and Clathrin-coated vesicle cargo loading, AP-3-mediated. Each is linked with POLB in more than 9 cancer types. Because this analysis shows association rather than direction, both POLB-to-partner and partner-to-POLB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Interkinetic nuclear migration grouped by POLB-low versus POLB-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POLB→partner) and Y-score (partner→POLB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Interkinetic nuclear migration →	+0.089	+0.868	<.001	<.001	3	10
LUNG_NSCLC_LUAD	Clathrin-coated vesicle cargo loading →	+0.111	+1.139	<.001	<.001	3	9
LUNG_NSCLC_LUAD	Clathrin-coated vesicle cargo loading, AP-3-mediated →	+0.111	+1.139	<.001	<.001	3	9
BREAST	Vesicle coating →	+0.072	+1.271	<.001	<.001	3	8
BLOOD_Lymphoma	Synaptic vesicle coating →	+0.109	+0.483	.001	.001	3	8
BONE	Microtubule anchoring at centrosome →	+0.123	+1.383	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,333 associations by consensus.

Interkinetic nuclear migration by POLB expression — BREAST

Explore this box plot interactively →