POLA1

Across TCGA pan-cancer cohorts, POLA1 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated POLA1 data layer compared with 25 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher POLA1 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated POLA1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, CESC, and COAD are the cancer types where POLA1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.909	0.296	.002	34	view →
CESC	OS	Median	III,IV	0.091	0.755	<.001	24	view →
COAD	OS	Median	III,IV	0.157	0.791	.001	18	view →
KIRC	OS	Median	All	0.596	0.874	.030	12	view →
LUSC	DFS	Median	All	0.213	0.533	.002	10	view →
PAAD	OS	Median	All	0.132	0.640	.018	6	view →
LUAD	OS	Median	III,IV	0.057	0.680	<.001	6	view →
ESCA	OS	Median	II,III,IV	0.216	0.702	.014	3	view →
SCLC	OS	Median	All	0.405	0.783	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

POLA1–UCEC (DFS)

Open the UCEC breakdown →