POLA1

Across TCGA patient cohorts, POLA1 mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLA1-associated genes across cancer lineages are CD49b, INPP4B, and TSC1. Each is linked with POLA1 in more than 3 cancer types. Because this analysis shows association rather than direction, both POLA1-to-partner and partner-to-POLA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD49b grouped by POLA1-low versus POLA1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLA1→partner) and Y-score (partner→POLA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CD49b →	+0.389	+3.008	.011	.019	3	4
COAD	INPP4B →	-0.490	-2.991	.011	.036	3	3
COAD	TSC1 →	-0.318	-2.991	.026	.036	3	3
LUSC	Raptor →	-0.228	-2.990	.043	.036	3	2
UCEC	JNK_pT183_Y185 →	-0.105	-1.184	.010	.019	3	2
UCEC	p53 →	-0.261	-1.247	.005	.038	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

CD49b by POLA1 expression — COAD

Explore this box plot interactively →