POLA1

Across TCGA cell cohorts, POLA1 mutation is significantly associated with the RNA expression of many other genes, with 199 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POLA1-associated genes across cancer lineages are F11, C3orf85, and ABCA12. Each is linked with POLA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both POLA1-to-partner and partner-to-POLA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, F11 grouped by POLA1-low versus POLA1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLA1→partner) and Y-score (partner→POLA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	F11 →	+0.060	+2.855	<.001	.002	3	2
LUNG_NSCLC_LUAD	C3orf85 →	+0.034	+2.797	<.001	.002	3	2
BLOOD_Leukemia	ABCA12 →	+0.544	+3.824	.003	.001	3	1
BLOOD_Leukemia	SLC2A2 →	+0.010	+2.556	<.001	.007	3	1
BLOOD_Leukemia	SCGB3A2 →	+0.064	+2.922	.001	.009	3	1
BLOOD_Leukemia	SPATA19 →	+0.010	+3.762	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 199 associations by consensus.

F11 by POLA1 expression — BLOOD_Leukemia

Explore this box plot interactively →