POGZ

Across TCGA pan-cancer cohorts, POGZ mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated POGZ data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher POGZ mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated POGZ expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

HNSC, COAD, and CCRCC are the cancer types where POGZ mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.646	0.900	.003	57	view →
COAD	DFS	Median	All	0.920	1.000	.014	36	view →
CCRCC	DFS	Tertile	III,IV	0.841	0.452	.006	16	view →
GBM	OS	Quartile	All	0.508	0.266	.049	2	view →
LSCC	OS	Quartile	II,III,IV	0.941	0.662	.038	2	view →
LUAD	OS	Median	All	0.971	0.760	.010	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

POGZ–HNSC (OS)

Open the HNSC breakdown →