POGZ

Across TCGA patient cohorts, POGZ mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POGZ-associated genes across cancer lineages are PDCD4, Cyclin-B1, and STAT3_pY705. Each is linked with POGZ in more than 3 cancer types. Because this analysis shows association rather than direction, both POGZ-to-partner and partner-to-POGZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by POGZ-low versus POGZ-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POGZ→partner) and Y-score (partner→POGZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.440	-2.070	<.001	.001	3	4
UCEC	Cyclin-B1 →	+0.540	+1.540	<.001	.001	3	3
UCEC	STAT3_pY705 →	-0.323	-1.540	<.001	.001	3	2
STAD	4E-BP1_pT37_T46 →	-0.369	-2.978	.030	.033	3	2
STAD	c-Kit →	-0.302	-3.000	.028	.034	3	2
UCEC	eIF4E →	+0.139	+3.013	.016	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

PDCD4 by POGZ expression — UCEC

Explore this box plot interactively →