POGZ

Across TCGA cell cohorts, POGZ mutation is significantly associated with the RNA expression of many other genes, with 134 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POGZ-associated genes across cancer lineages are CSN2, NOBOX, and PF4V1. Each is linked with POGZ in more than 1 cancer types. Because this analysis shows association rather than direction, both POGZ-to-partner and partner-to-POGZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CSN2 grouped by POGZ-low versus POGZ-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POGZ→partner) and Y-score (partner→POGZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CSN2 →	+0.023	+4.643	<.001	.008	3	2
LUNG_NSCLC_LUSC	NOBOX →	+0.040	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	PF4V1 →	+0.296	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	RXFP2 →	+0.023	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	OR13C9 →	+0.090	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	KIF2B →	+0.046	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 134 associations by consensus.

CSN2 by POGZ expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →