POGLUT3

Across TCGA patient cohorts, POGLUT3 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POGLUT3-associated genes across cancer lineages are EGFR, FoxM1, and Rab25. Each is linked with POGLUT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both POGLUT3-to-partner and partner-to-POGLUT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by POGLUT3-low versus POGLUT3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POGLUT3→partner) and Y-score (partner→POGLUT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.206	-2.321	.010	.035	3	1
UCEC	FoxM1 →	+0.351	+3.459	.006	.005	3	1
UCEC	Rab25 →	-0.454	-2.321	.006	.035	3	1
UCEC	STAT3_pY705 →	-0.471	-3.459	<.001	.005	3	1
UCEC	YAP →	+0.155	+2.179	.040	.034	3	1
UCEC	ATM →	-0.586	-3.459	.010	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

EGFR by POGLUT3 expression — UCEC

Explore this box plot interactively →