POGLUT1

Across TCGA pan-cancer cohorts, POGLUT1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of POGLUT1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where POGLUT1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types POGLUT1 is over-expressed in tumor.

HNSC, CCRCC, and COAD are the cancer types where POGLUT1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POGLUT1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.442	<.001	11	view →
CCRCC	All	II,III,IV	+0.259	<.001	11	view →
COAD	All	III,IV	+0.174	<.001	8	view →
LSCC	Male	All	+0.288	<.001	7	view →
PDAC	All	II,III,IV	+0.277	.001	4	view →
LUAD	All	All	+0.109	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

POGLUT1–HNSC

Open the HNSC breakdown →