POGLUT1

Across TCGA patient cohorts, POGLUT1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POGLUT1-associated genes across cancer lineages are JNK2, Notch1, and Caveolin-1. Each is linked with POGLUT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both POGLUT1-to-partner and partner-to-POGLUT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by POGLUT1-low versus POGLUT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POGLUT1→partner) and Y-score (partner→POGLUT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.242	+2.169	.001	.003	3	2
UCEC	Notch1 →	+0.123	+2.598	.019	.005	3	2
UCEC	Caveolin-1 →	-0.565	-2.459	.038	.018	3	2
UCEC	EGFR_pY1068 →	-0.194	-2.169	.039	.003	3	1
UCEC	ERK2 →	+0.166	+1.765	.021	.014	3	1
UCEC	INPP4B →	-0.252	-2.584	.038	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

JNK2 by POGLUT1 expression — UCEC

Explore this box plot interactively →