POGK

Across TCGA pan-cancer cohorts, POGK Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated POGK data layer compared with 22 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher POGK Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated POGK expression acts as an unfavorable survival marker.

COAD, SCLC, and SKCM are the cancer types where POGK Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.307	0.790	<.001	32	view →
SCLC	OS	Median	All	0.082	0.708	<.001	12	view →
SKCM	OS	Median	III,IV	0.072	0.814	<.001	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

POGK–COAD (DFS)

Open the COAD breakdown →