POGK

Across TCGA pan-cancer cohorts, POGK mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated POGK data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher POGK mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated POGK expression acts as an unfavorable survival marker, although some lineages such as PDAC and GBM show a favorable association.

CCRCC, HNSC, and PDAC are the cancer types where POGK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.653	1.000	.001	91	view →
HNSC	OS	Median	III,IV	0.774	0.926	.002	31	view →
PDAC	DFS	Median	II,III,IV	0.524	0.297	.012	11	view →
LSCC	OS	Median	II,III,IV	0.810	1.000	.035	5	view →
GBM	OS	Quartile	All	0.546	0.246	.030	3	view →
LUAD	DFS	Median	III,IV	1.000	0.498	.017	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

POGK–CCRCC (DFS)

Open the CCRCC breakdown →