POGK

Across TCGA patient cohorts, POGK mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POGK-associated genes across cancer lineages are Di-Ras3, GATA6, and JNK_pT183_Y185. Each is linked with POGK in more than 2 cancer types. Because this analysis shows association rather than direction, both POGK-to-partner and partner-to-POGK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Di-Ras3 grouped by POGK-low versus POGK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POGK→partner) and Y-score (partner→POGK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Di-Ras3 →	-0.150	-3.571	.002	.002	3	3
UCEC	GATA6 →	-0.133	-1.859	.016	.048	3	2
UCEC	JNK_pT183_Y185 →	-0.161	-1.584	.004	.034	3	2
UCEC	Annexin-1 →	+0.412	+1.604	.021	.041	3	2
UCEC	TFRC →	+0.502	+3.584	.005	.002	3	2
UCEC	Caspase-7-cleavedD198 →	+0.433	+2.115	.032	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Di-Ras3 by POGK expression — UCEC

Explore this box plot interactively →