POGK

Across TCGA cell cohorts, POGK mutation is significantly associated with the RNA expression of many other genes, with 354 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POGK-associated genes across cancer lineages are APCS, OR4F4, and MRGPRX2. Each is linked with POGK in more than 1 cancer types. Because this analysis shows association rather than direction, both POGK-to-partner and partner-to-POGK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, APCS grouped by POGK-low versus POGK-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POGK→partner) and Y-score (partner→POGK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	APCS →	+0.042	+4.643	<.001	.004	3	1
LUNG_SCLC	OR4F4 →	+0.012	+4.643	<.001	.004	3	1
LUNG_SCLC	MRGPRX2 →	+0.014	+4.817	<.001	.001	3	1
LUNG_SCLC	HTN3 →	+0.077	+4.269	<.001	.005	3	1
LUNG_SCLC	PPIAL4E →	+0.027	+4.643	<.001	.004	3	1
LARGE_INTESTINE	ANKRD54 →	+0.527	+3.299	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 354 associations by consensus.

APCS by POGK expression — LUNG_SCLC

Explore this box plot interactively →