Across TCGA pan-cancer cohorts, POFUT2 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated POFUT2 data layer compared with 28 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher POFUT2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated POFUT2 expression acts as an unfavorable survival marker, although some lineages such as STAD show a favorable association.

ESCA, LUSC, and UCEC are the cancer types where POFUT2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.124	0.703	<.001	30	view →
LUSC	OS	Median	All	0.453	0.780	.001	27	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
STAD	OS	Median	III,IV	1.000	0.367	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: POFUT2 tumor-vs-normal RNA expression · all POFUT2 data types