Across TCGA patient cohorts, POFUT2 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POFUT2-associated genes across cancer lineages are GAPDH, PRDX1, and ATM. Each is linked with POFUT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both POFUT2-to-partner and partner-to-POFUT2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POFUT2→partner) and Y-score (partner→POFUT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GAPDH →	+0.534	+2.330	.019	.020	3	2
COAD	PRDX1 →	+0.197	+2.824	.004	.034	3	2
COAD	ATM →	-0.630	-2.313	<.001	.035	3	2
COAD	Caveolin-1 →	-0.975	-3.450	.002	.005	3	2
UCEC	Caspase-8 →	-0.309	-2.874	<.001	<.001	3	2
UCEC	4E-BP1 →	+0.321	+2.351	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Exploration

POFUT2 survival (RNA) · tumor vs normal (RNA) · all POFUT2 data types