POFUT1

Across TCGA pan-cancer cohorts, POFUT1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated POFUT1 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher POFUT1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated POFUT1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

CCRCC, UCEC, and LUAD are the cancer types where POFUT1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.373	0.744	.003	34	view →
UCEC	OS	Quartile	II,III,IV	0.333	1.000	.009	20	view →
LUAD	OS	Quartile	III,IV	0.329	1.000	.028	6	view →
HNSC	DFS	Median	III,IV	1.000	0.939	.043	1	view →
LSCC	DFS	Quartile	All	0.929	0.769	.037	1	view →
GBM	DFS	Tertile	All	0.866	0.599	.032	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

POFUT1–CCRCC (DFS)

Open the CCRCC breakdown →