POFUT1

Across TCGA patient cohorts, POFUT1 mutation is significantly associated with the RNA expression of many other genes, with 1,134 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POFUT1-associated genes across cancer lineages are RN7SKP1, RNU1-19P, and RNA5SP90. Each is linked with POFUT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both POFUT1-to-partner and partner-to-POFUT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP1 grouped by POFUT1-low versus POFUT1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POFUT1→partner) and Y-score (partner→POFUT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RN7SKP1 →	+0.460	+4.484	<.001	.002	3	3
COAD	RNU1-19P →	+1.992	+4.374	<.001	.002	3	2
COAD	RNA5SP90 →	+1.522	+4.602	<.001	.001	3	2
COAD	TANK-AS1 →	+0.923	+4.271	<.001	.003	3	2
COAD	PGAM3P →	+0.130	+5.557	<.001	.001	3	2
COAD	MRPS35P2 →	+0.611	+4.666	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,134 associations by consensus.

RN7SKP1 by POFUT1 expression — COAD

Explore this box plot interactively →