POFUT1

Across TCGA patient cohorts, POFUT1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POFUT1-associated genes across cancer lineages are Notch1, S6_pS240_S244, and ASNS. Each is linked with POFUT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both POFUT1-to-partner and partner-to-POFUT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by POFUT1-low versus POFUT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POFUT1→partner) and Y-score (partner→POFUT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.188	+2.594	.001	.006	3	2
UCEC	S6_pS240_S244 →	+0.386	+2.906	.025	.001	3	2
UCEC	ASNS →	+0.517	+2.321	<.001	.033	3	2
UCEC	Caspase-8 →	-0.230	-2.000	.031	.030	3	2
UCEC	14-3-3_beta →	-0.096	-1.687	.024	.044	3	1
UCEC	PR →	-0.256	-3.321	.016	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Notch1 by POFUT1 expression — UCEC

Explore this box plot interactively →