POFUT1

Across TCGA cell cohorts, POFUT1 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible POFUT1-associated genes across cancer lineages are RBMY1E, PAX1, and TACR3. Each is linked with POFUT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both POFUT1-to-partner and partner-to-POFUT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBMY1E grouped by POFUT1-low versus POFUT1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POFUT1→partner) and Y-score (partner→POFUT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	RBMY1E →	+0.030	+5.357	<.001	.003	3	1
BLOOD_Leukemia	PAX1 →	+0.053	+5.060	<.001	.001	3	1
BLOOD_Leukemia	TACR3 →	+0.035	+5.060	<.001	.001	3	1
BLOOD_Leukemia	PRND →	+0.011	+4.874	<.001	.002	3	1
BLOOD_Leukemia	FAM9A →	+0.014	+4.539	<.001	.007	3	1
BLOOD_Leukemia	OR10T2 →	+0.595	+4.276	.004	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

RBMY1E by POFUT1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →