POF1B

Across TCGA pan-cancer cohorts, POF1B mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated POF1B data layer compared with 21 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher POF1B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated POF1B expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

COAD, PDAC, and LUAD are the cancer types where POF1B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.921	.015	78	view →
PDAC	OS	Quartile	All	0.670	0.352	<.001	66	view →
LUAD	DFS	Quartile	II,III,IV	0.797	1.000	.005	24	view →
HNSC	DFS	Median	All	0.868	0.682	.010	20	view →
CCRCC	OS	Median	All	1.000	0.593	.005	6	view →
UCEC	DFS	Quartile	II,III,IV	0.492	1.000	.018	4	view →
GBM	DFS	Median	All	0.322	0.840	.010	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

POF1B–COAD (DFS)

Open the COAD breakdown →