POF1B

Across TCGA patient cohorts, POF1B mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POF1B-associated genes across cancer lineages are ATM, eEF2, and eIF4E. Each is linked with POF1B in more than 2 cancer types. Because this analysis shows association rather than direction, both POF1B-to-partner and partner-to-POF1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by POF1B-low versus POF1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POF1B→partner) and Y-score (partner→POF1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.528	-2.000	<.001	<.001	3	3
UCEC	eEF2 →	+0.354	+1.584	<.001	.001	3	2
UCEC	eIF4E →	+0.152	+1.222	.011	.011	3	2
UCEC	ERK2 →	+0.143	+1.392	.008	.017	3	2
SKCM	GATA6 →	-0.194	-2.072	.010	.004	3	2
UCEC	MEK1 →	+0.386	+2.736	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

ATM by POF1B expression — UCEC

Explore this box plot interactively →