PODXL2

Across TCGA pan-cancer cohorts, PODXL2 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PODXL2 data layer compared with 26 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in prostate adenocarcinoma (PRAD), where higher PODXL2 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PODXL2 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

PRAD, HNSC, and LIHC are the cancer types where PODXL2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
HNSC	OS	Median	All	0.177	0.710	.016	6	view →
LIHC	DFS	Median	II,III,IV	0.044	0.427	<.001	6	view →
SKCM	DFS	Median	All	0.547	0.188	.011	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PODXL2–PRAD (DFS)

Open the PRAD breakdown →