PODXL2

Across TCGA patient cohorts, PODXL2 mutation is significantly associated with the RNA expression of many other genes, with 1,876 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PODXL2-associated genes across cancer lineages are NCAPD3, ZNF761, and STIP1. Each is linked with PODXL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PODXL2-to-partner and partner-to-PODXL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NCAPD3 grouped by PODXL2-low versus PODXL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PODXL2→partner) and Y-score (partner→PODXL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NCAPD3 →	+0.664	+3.592	.001	.001	3	2
UCEC	ZNF761 →	+0.516	+2.593	.002	.006	3	2
UCEC	STIP1 →	+0.484	+3.000	.003	.001	3	2
UCEC	RIC8A →	+0.412	+2.332	.002	.003	3	2
UCEC	DEPDC1 →	+0.672	+2.332	.006	.003	3	2
UCEC	R3HDM1 →	+0.572	+3.592	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,876 associations by consensus.

NCAPD3 by PODXL2 expression — UCEC

Explore this box plot interactively →