PODXL2

Across TCGA patient cohorts, PODXL2 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PODXL2-associated genes across cancer lineages are JNK2, MEK1, and MSH2. Each is linked with PODXL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PODXL2-to-partner and partner-to-PODXL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by PODXL2-low versus PODXL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PODXL2→partner) and Y-score (partner→PODXL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.217	+2.115	.012	.019	3	1
UCEC	MEK1 →	+0.457	+3.584	.004	.002	3	1
UCEC	MSH2 →	-0.300	-2.575	.002	.010	3	1
UCEC	p62 Lck ligand →	+0.339	+3.009	.017	.019	3	1
UCEC	PCNA →	+0.242	+2.807	.010	.003	3	1
UCEC	PDCD4 →	-0.517	-2.312	.011	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

JNK2 by PODXL2 expression — UCEC

Explore this box plot interactively →