PODXL2

Across TCGA cell cohorts, PODXL2 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PODXL2-associated genes across cancer lineages are PAX4, C5orf52, and TBATA. Each is linked with PODXL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PODXL2-to-partner and partner-to-PODXL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAX4 grouped by PODXL2-low versus PODXL2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PODXL2→partner) and Y-score (partner→PODXL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PAX4 →	+0.019	+4.467	.001	.004	3	1
SKIN	C5orf52 →	+0.046	+4.415	<.001	.007	3	1
LUNG_NSCLC_LUAD	TBATA →	+0.252	+4.544	<.001	.003	3	1
BLOOD_Leukemia	SCGB1D2 →	+0.088	+3.855	.009	.007	3	1
BLOOD_Leukemia	TMEM196 →	+0.044	+5.289	<.001	<.001	3	1
BLOOD_Leukemia	IFNA1 →	+0.152	+4.269	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

PAX4 by PODXL2 expression — SKIN

Explore this box plot interactively →