PODXL

Across TCGA pan-cancer cohorts, PODXL mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PODXL data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PODXL mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PODXL expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

PDAC, CCRCC, and LSCC are the cancer types where PODXL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	All	0.265	0.499	.001	58	view →
CCRCC	DFS	Median	III,IV	0.778	0.387	.001	20	view →
LSCC	DFS	Quartile	II,III,IV	0.789	1.000	.011	10	view →
GBM	OS	Tertile	All	0.233	0.468	.007	7	view →
HNSC	DFS	Median	III,IV	0.939	1.000	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PODXL–PDAC (OS)

Open the PDAC breakdown →