PODXL

Across TCGA patient cohorts, PODXL mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PODXL-associated genes across cancer lineages are p38-MAPK_pT180_Y182, p62 Lck ligand, and STAT3_pY705. Each is linked with PODXL in more than 1 cancer types. Because this analysis shows association rather than direction, both PODXL-to-partner and partner-to-PODXL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by PODXL-low versus PODXL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PODXL→partner) and Y-score (partner→PODXL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.338	-2.115	.045	.017	3	2
UCEC	p62 Lck ligand →	+0.336	+2.009	.005	.005	3	2
UCEC	STAT3_pY705 →	-0.447	-3.807	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.211	-1.415	.025	.046	3	1
UCEC	eIF4E →	+0.201	+2.321	.011	.005	3	1
UCEC	A-Raf_pS299 →	-0.162	-2.000	<.001	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

p38-MAPK_pT180_Y182 by PODXL expression — UCEC

Explore this box plot interactively →