PODXL

Across TCGA cell cohorts, PODXL RNA expression is significantly associated with the RNA expression of many other genes, with 9,126 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PODXL-associated genes across cancer lineages are MAP4K4, TPX2, and ABL2. Each is linked with PODXL in more than 7 cancer types. Because this analysis shows association rather than direction, both PODXL-to-partner and partner-to-PODXL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PODXL versus MAP4K4 in BREAST, with a Pearson correlation of 0.56.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PODXL→partner) and Y-score (partner→PODXL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MAP4K4 →	+1.788	+1.525	<.001	<.001	3	6
KIDNEY	TPX2 →	+1.391	+1.992	<.001	.004	2	7
LIVER	ABL2 →	+1.753	+3.206	<.001	.008	2	7
OESOPHAGUS	PLCD3 →	+1.532	+2.626	.002	<.001	3	6
SKIN	AFAP1 →	+1.475	+2.154	<.001	<.001	3	6
LUNG_NSCLC_LUSC	ARHGAP23 →	+3.172	+2.732	<.001	.003	1	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,126 associations by consensus.

PODXL vs MAP4K4 — BREAST

Explore this scatter interactively →