PODXL

Across TCGA cell cohorts, PODXL RNA expression is significantly associated with the go_rna of many other GO terms, with 4,224 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PODXL-associated GO terms across cancer lineages are Regulation of microvillus organization, Regulation of microvillus assembly, and Negative regulation of cell cycle phase transition. Each is linked with PODXL in more than 11 cancer types. Because this analysis shows association rather than direction, both PODXL-to-partner and partner-to-PODXL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of microvillus organization grouped by PODXL-low versus PODXL-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PODXL→partner) and Y-score (partner→PODXL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Regulation of microvillus organization →	+0.107	+3.087	<.001	<.001	3	12
LUNG_SCLC	Regulation of microvillus assembly →	+0.133	+2.299	<.001	<.001	3	12
KIDNEY	Negative regulation of cell cycle phase transition →	+0.061	+2.004	<.001	<.001	3	11
PANCREAS	Regulation of cell-cell adhesion mediated by integrin →	+0.192	+2.399	<.001	<.001	3	10
BONE	Podocyte development →	+0.306	+2.571	<.001	<.001	3	10
SOFT_TISSUE	RNA export from nucleus →	+0.091	+2.889	.003	<.001	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,224 associations by consensus.

Regulation of microvillus organization by PODXL expression — OVARY

Explore this box plot interactively →