PODNL1

Across TCGA pan-cancer cohorts, PODNL1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PODNL1 data layer compared with 26 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher PODNL1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PODNL1 expression acts as an unfavorable survival marker.

ESCA, SCLC, and GBM are the cancer types where PODNL1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	All	0.114	0.704	<.001	18	view →
SCLC	DFS	Median	All	0.233	0.630	.028	6	view →
GBM	DFS	Median	All	0.048	0.242	.006	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PODNL1–ESCA (OS)

Open the ESCA breakdown →