PODNL1

Across TCGA patient cohorts, PODNL1 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PODNL1-associated genes across cancer lineages are Ku80, STAT3_pY705, and C-Raf. Each is linked with PODNL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PODNL1-to-partner and partner-to-PODNL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by PODNL1-low versus PODNL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PODNL1→partner) and Y-score (partner→PODNL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.302	+3.013	.027	.019	3	1
UCEC	STAT3_pY705 →	-0.340	-3.000	.025	.037	3	1
UCEC	C-Raf →	+0.247	+3.000	.002	.037	3	1
UCEC	Rab11 →	-0.200	-3.000	.017	.037	2	1
UCEC	p62 Lck ligand →	+0.501	+3.000	.007	.037	1	1
UCEC	Rad50 →	-0.292	-3.000	.037	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Ku80 by PODNL1 expression — UCEC

Explore this box plot interactively →