PODNL1

Across TCGA cell cohorts, PODNL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,305 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PODNL1-associated GO terms across cancer lineages are Regulation of cell-substrate junction assembly, Positive regulation of cell-substrate adhesion, and Regulation of cell-matrix adhesion. Each is linked with PODNL1 in more than 8 cancer types. Because this analysis shows association rather than direction, both PODNL1-to-partner and partner-to-PODNL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cell-substrate junction assembly grouped by PODNL1-low versus PODNL1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PODNL1→partner) and Y-score (partner→PODNL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of cell-substrate junction assembly →	+0.126	+1.662	<.001	<.001	3	8
BONE	Positive regulation of cell-substrate adhesion →	+0.168	+2.142	<.001	<.001	3	8
LIVER	Regulation of cell-matrix adhesion →	+0.137	+2.482	<.001	.002	3	8
LIVER	Regeneration →	+0.132	+2.417	<.001	.002	3	8
LUNG_NSCLC_LUAD	Response to acid chemical →	+0.055	+1.025	.002	<.001	2	9
BREAST	Negative regulation of protein catabolic process →	+0.054	+0.766	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,305 associations by consensus.

Regulation of cell-substrate junction assembly by PODNL1 expression — BONE

Explore this box plot interactively →