PODNL1

Across TCGA cell cohorts, PODNL1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PODNL1-associated genes across cancer lineages are PPP1R17, KCNA1, and TTLL8. Each is linked with PODNL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PODNL1-to-partner and partner-to-PODNL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP1R17 grouped by PODNL1-low versus PODNL1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PODNL1→partner) and Y-score (partner→PODNL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PPP1R17 →	+0.073	+3.882	<.001	.001	3	1
LARGE_INTESTINE	KCNA1 →	+0.031	+3.994	.002	.002	3	1
LARGE_INTESTINE	TTLL8 →	+0.003	+4.022	<.001	.006	3	1
LARGE_INTESTINE	ACSM6 →	+0.028	+3.658	<.001	.005	3	1
LARGE_INTESTINE	GSG1L2 →	+0.013	+4.022	<.001	.006	3	1
LARGE_INTESTINE	SLC17A6 →	+0.013	+3.977	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

PPP1R17 by PODNL1 expression — LARGE_INTESTINE

Explore this box plot interactively →