POC5

Across TCGA patient cohorts, POC5 mutation is significantly associated with the RNA expression of many other genes, with 1,288 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POC5-associated genes across cancer lineages are TRDD1, OR1E3, and H4C7. Each is linked with POC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both POC5-to-partner and partner-to-POC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRDD1 grouped by POC5-low versus POC5-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POC5→partner) and Y-score (partner→POC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TRDD1 →	+1.367	+9.057	<.001	.003	3	2
LUAD	OR1E3 →	+0.125	+5.554	<.001	.004	3	2
LUAD	H4C7 →	+0.203	+5.044	<.001	.009	3	2
UCEC	RNA5SP410 →	+0.598	+1.895	<.001	.007	3	2
COAD	RN7SL835P →	+0.260	+3.868	.002	.003	3	2
COAD	RN7SL440P →	+0.103	+3.428	.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,288 associations by consensus.

TRDD1 by POC5 expression — BRCA

Explore this box plot interactively →